Prevention and appropriate management of wound infection is central
to promote the healing process. While not all wounds will necessitate
use of systemic antibiotics, some may benefit from the use of topical
antimicrobials as part of a holistic standard of care. This article describes
five different cases, from China, where the clinicians used Technology
Lipido-Colloid Silver Non-Adherent (TLC-Ag) dressings as part of their
holistic multidisciplinary wound management strategy. The wounds
discussed were mainly chronic, including two venous leg ulcers and
lymphoedema ulcer, a post-amputation wound as well as a case of
pyoderma gangrenosum. Managing these wounds with TLC-Ag as a part
of the standard holistic multidisciplinary care provided resulted in positive
outcomes for the patients.
Archives
When the Tissue Viability Nurse becomes a patient reflections on a personal journey
This paper presents a reflection of my journey as a patient following a breast
abscess. As an experienced community nurse with a specialist interest in tissue
viability, we daily assess a range of different wound types and are adept at early
identification and management of an infected wound. We instinctively know which
dressing type to use to manage localised wound infection and slough and reduce
pain for patients; however, when the nurse becomes the patient with a wound and
has welcomed a new born child into the world, we can suddenly lose the specialist
knowledge. This paper reflects on a journey I recently experienced.
Silver Dressings for the Healing of Venous Leg Ulcer a Meta-Analysis and Systematic Review
Abstract
This study was aimed to evaluate whether silver-containing dressings were superior to other types of dressings in the treatment of
venous leg ulcers (VLU) and their specific advantages.
Eight databases (Cochrane Library, PubMed, Web of Science, Ovid-Medline, Wanfang, VIP, China Biology Medicine, and China
National Knowledge Infrastructure) were systematically reviewed from inception to May 2019 for randomized controlled trials (RCTs).
The primary outcome was complete wound healing, and the secondary outcomes included absolute wound size changes (change of
cm2 area since baseline), relative changes (percentage change of area relative to baseline), and healing rate. Two reviewers
independently evaluated the risk of bias using the Cochrane Collaboration assessment tool and extracted the data according to the
predesigned table. All analyses were performed using the latest Review Manager Software (version 5.3).
A total of 8 studies qualified and were included in the meta-analysis, including 1057 patients (experiment: 526, control: 531). Both
complete wound healing and wound healing rates were reported in 5 studies. Two and 3 studies reported the effect of silver
dressings on absolute and relative wound size changes, respectively. Most of the studies used intention-to-treat analysis.
There was sufficient evidence that silver-containing dressings can accelerate the healing rate of chronic VLU and improve their
healing in a short duration of time. However, compared with other dressings, clinical trials with long-term follow-up data are needed to
confirm whether silver dressings have advantages regarding complete wound healing.
Abbreviations: CBM = China Biology Medicine, CI = confidence interval, CNKI = China National Knowledge Infrastructure,
PRISMA = Preferred Reporting Items for Systematic Reviews and Meta-Analysis, Q test = Chi-Squared test, RCTs = randomized
controlled trials, RD = risk difference, SMD = standardized mean difference, VLU = venous leg ulcers, WMD = weighted mean
difference.
Keywords: silver dressings, venous leg ulcer, wound healing, meta-analysis
Addressing Wound Chronicity Factors UrgoClean AG® and UrgoStart® Case Studies
Chronic wounds are a perennial problem in clinical practice and place a burden
on patients, their families and healthcare providers. By addressing factors that
contribute to chronicity (slough, biofilm, elevated levels of metalloproteinases
and impaired angiogenesis), in addition to managing a patient’s comorbidities,
nutritional status and lifestyle, there is a greater chance of healing. This article
discusses the mechanisms by which UrgoClean Ag and UrgoStart support a
healthy wound environment, along with two case studies of their use in practice.
A Prospective Randomized Study The Usefulness and Efficacy of Negative Pressure Wound Therapy with Lipido-Colloid Polyester Mesh Compared to Traditional Negative Pressure Wound Therapy for Treatment of Pressure Ulcers
To improve healing of pressure ulcer wounds, it is important to optimize the conditions
of the area surrounding the wound. Negative pressure wound therapy (NPWT) promotes wound
healing, however, the removal of NPWT can cause pain or focal bleeding, delaying wound healing or
causing infection. In this study, we reviewed the e cacy of the lipidocolloid non-adherent dressing
(Urgotul®) as a wound contact layer. A total of 38 patients from the same facility who applied
NPWT from April 2016 to October 2019 were included and divided into two groups; NPWT with
the lipidocolloid non-adherent dressing (group 1, experimental group, 19 patients) and NPWT only
(group 2, control group, 19 patients). The condition of the wound was examined prior to NPWT
application, at one week, and again at three weeks after application. No significant di erences were
found between groups for general characteristics, bacterial culture or photo analysis. However,
when comparing groups based on the time of examination, there was a significant reduction of the
wound size in group 1 (p = 0.001) but not in group 2 (p = 0.082). Therefore, the current study finds
that using the lipidocolloid non-adherent dressing as a wound contact layer in NPWT stimulates
healing by shrinking the size of the pressure ulcer wound.
Moving the chronic wound along the healing trajectory
Chronic wounds are an ever-growing challenge for clinicians and represent a
huge burden on healthcare resources (Harding, 2002). They have been referred
to as a silent epidemic that is affecting a large number of people in the world
population (Gottrup, 2004). However, due to a better understanding of what
makes a wound chronic, several new treatments that offer better outcomes
for the patient and a broader choice for the clinician have been developed
(Harding, 2002). A sterile, non-adherent, slough-trapping, poly-absorbent fibre
dressing with the technologie lipido-colloïde (TLC) healing matrix to promote
wound healing and enable pain-free dressing changes, which can be used for
gentle desloughing, has been developed by Urgo. The slough-trapping fibres
(poly-absorbent) have been shown to bind and trap the slough within the
dressing, providing safe and effective desloughing (Kelly et al, 2013), while the
silver lipido-colloid matrix in the antimicrobial version, has been established
in its efficacy in the management of chronic wounds presenting with a risk
of infection as demonstrated through previous randomised controlled trials
(Harding et al, 2012; Lazareth et al, 2012).
Clinical Evaluation of Technology Lipido-Colloid in the Management of Acute Wounds in China
Wound management has evolved from considering wound
dressings as a means to provide protection to a medium that enhances
wound healing and also takes into consideration patient aspects such as
atraumatic removal. Technology-lipido colloid (TLC) is described as a healing
matrix as it stimulates fibroblasts, which is achieved through maintaining a
moist wound environment. It also provides atraumatic removal, thus it not
only protects the wound but avoids unnecessary pain for the patients. This
article discusses five cases from China where the TLC was used on a variety
of wounds with positive outcomes both for the wound and the patients.
Evaluation of NOSF in Neuropathic Diabetic Foot Ulcers
Both case studies feature neuropathic patients who have good lower limb arterial blood flow and there is an expectancy these wounds will heal. However, it is the speed of healing that is interesting, as well as the fact
that these wounds were progressed from a non/slow-healing state into a healed state. Of particular interest is the fact that Case Study 1 healed without the use of adequate pressure relief (the patient was non-compliant with the use of an Aircast boot). Pressure relief is an integral part of wound healing (NICE, 2004) and this factor alone could have been the cause of non-healing. Since the wound healed despite pressure relief not being adequate, this would indicate that, in this case, Urgostart Contact dressing was effective.UrgoStart Contact can be used effectively in the management of neuropathic diabetic foot wounds, however, the author has not been involved in case studies that demonstrate its effectiveness on diabetic neuroischaemic wounds.
Use of Nano-Oligosaccharide Factor (Sucrose Octasulfate) Dressing Based on Technology Lipido-Colloid (TLC-NOSF) as an Interface Layer with Negative Pressure Wound Therapy
Complex and complicated wounds (CCWs) tend to exhibit slow wound healing and poor prognoses despite good standards of care. Numerous literature demonstrated the efficacy of TLC-NOSF dressing (UrgoStart®) in healing of both acute and chronic wounds. The author thus hypothesised that inclusion of TLC-NOSF dressing in dressing regimes would enhance wound healing and improve outcomes in CCW. This paper successfully verifies the hypothesis on three such
wounds, with good wound healing outcomes achieved.
Diabetic Foot Ulcer Management with TLC-NOSF (Technology Lipido-Colloid Nano-Oligosaccharide Factor) Wound Dressings from China
Diabetes and its associated complications is one of the biggest burdens that healthcare providers face. Diabetic foot ulcers (DFUs) are difficult-toheal wounds resulting from the diabetes-related pathogenic abnormalities.
Statistics from China are high, with the largest global prevalence of people with diabetes, and the local expenditure for this disease is second only to the US (Zhang et al, 2021). Moreover, 20% to 33% of costs related to diabetes mellitus are used for treatments of the diabetic foot (Chun et al, 2019). International and Chinese national guidelines broadly agree on the standard of care for the management of diabetic foot ulcers and it is very well understood that evidence-based holistic management, including local wound dressings, can improve healing outcomes. The clinical cases portrayed are aimed at describing the attainment of the implementation of Technology-Lipido-Colloid Nano-Oligosaccharide Factor dressing (TLC-NOSF). The TLC-NOSF dressing has been included in recent recommendations by the International Working Group on the Diabetic Foot (IWGDF) 2019 Guidelines and the National Institute for Health and Care Excellence (NICE, UK) and was the focus of a recently published systematic review highlighting the robust evidence behind this technology